التقدير الطيفي لأدوية الكاتيكول امين المثيل دوبا والإيزوبرينالين في الصورة النقية وفي المستحضرات الصيدلانية

القسم: Article
إصدار
مجلد 21 عدد 3 (2025): المجلد 21 العدد 3
منشور
Sep 1, 2025
##editor.issues.pages##
576-599

الملخص

م استخدام طريقتين طيفيتين بسيطتين وسريعتين وعاليتي الحساسية ودقيقتين لتقدير دوائي الكاتيكول امين المثيل دوبا الإيزوبرينالين. تم استخدام تفاعل الاقتران التأكسدي لتقدير المثيل دوبا باستخدام نترات الحديديك كعامل مؤكسد واقترانه بكاشف ميزالازين في وسط قاعدي من محلول هيدروكسيد الصوديوم ليعطي ناتج أزرق اللون وتم قياس الامتصاص عند الطول الموجي578 نانوميتر وكانت خطية منحنى المعايرة في نطاق التركيز 2 -28 مايكروغرام/مليلتر مع معامل ارتباط 0.9986 وتم حساب قيم الامتصاص المولاري وحساسية ساندل وكانا يساويان 0.566 ×410 لتر. مول-1. سم-1 و0.042 ميكروغرام. سم-2 على التوالي، كانت قيم حد الكشف وحد ​​التقدير الكمي تساوي 0.06509 و0.2169 مايكروغرام/مليلتر على التوالي. تم تقدير الايزوبرينالين باستخدام تفاعل الاقتران الآزوي باستخدام كاشف البارا-نيتروانيلين المؤزوت مقترنًا مع الايزوبرينالين في وسط قاعدي من محلول هيدروكسيد الصوديوم بوجود محلول TritonX-100 (1٪) ليتم إنتاج صبغة الآزو البرتقالية الحمراء التي تم قياس امتصاصها عند الطول الموجي 510 نانوميتر، وكانت خطية منحنى المعايرة في نطاق التركيز بين 2 -20 مايكروغرام/مليلتر مع معامل ارتباط 0.9985، وتم حساب قيم الامتصاص المولاري وحساسية ساندل وكانا 2.3434 ×410 لتر. مول-1. سم-1 و0.0105 ميكروغرام. سم-2 على التوالي، كانت حد الكشف وحد التقدير الكمي تساوي 0.02119 و0.07064 مايكروغرام/مليلتر على التوالي. وقد أثبتت الطريقتان نجاحهما في تقدير مستويات المثيل دوبا الإيزوبرينالين في أشكالهما النقية وفي المستحضرات الصيدلانية.

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المؤلفون

هند خالد سلمان

University of Mosul, College of Science, Department of Chemistry, Mosul, Iraq.

خالدة محمد عمر

جامعة الموصل كلية العلوم قسم الكيمياء

المعرفات

https://doi.org/10.33899/berj.2025.Vol21.Iss3.53547
تنزيل هذا الملف
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الإحصائيات

كيفية الاقتباس

Hind Khalid Salman, & Khalida Mohammed Omar. (2025). التقدير الطيفي لأدوية الكاتيكول امين المثيل دوبا والإيزوبرينالين في الصورة النقية وفي المستحضرات الصيدلانية. مجلة ابحاث كلية التربية الاساسية, 21(3), 576–599. https://doi.org/10.33899/berj.2025.Vol21.Iss3.53547